Absence of Functional Messenger RNA Activity for Beta Globin Chain Synthesis in f3#{176}-Thalassemia
نویسنده
چکیده
Functional human globin messenger RNA but failed to stimulate the synthesis of any was isolated from reticulocytes of two paf. -chains, even though nonthalassemic tients with homozygous /3#{176}-thalassemia, human globin mRNA preparations conthree patients with sickle cell fl#{176}-thalassistently stimulated two to four times as semia, and one patient doubly heteromuch fl or globin chain synthesis as zygous for fl#{176}-thalassemia and hemoa-chain synthesis when incubated in the globin Lepore. When incubated in the same system under the same conditions. Krebs type II mouse ascites tumor-cellThese results strongly suggest that funcfree system, messenger RNA from these tional fl’-chain-specific globin mRNA is patients actively directed the synthesis of absent in fl#{176}-thalassemia. human fiS and/or aand ‘y-globin chains
منابع مشابه
Absence of Functional Messenger RNA Activity for Beta Globin Chain Synthesis in f3#{176}-Thalassemia
Functional human globin messenger RNA but failed to stimulate the synthesis of any was isolated from reticulocytes of two paf. -chains, even though nonthalassemic tients with homozygous /3#{176}-thalassemia, human globin mRNA preparations conthree patients with sickle cell fl#{176}-thalassistently stimulated two to four times as semia, and one patient doubly heteromuch fl or globin chain synthe...
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